Founder & CEO, Wealthing VC Club

For years I thought doing well and doing good were a trade-off.

I didn't like the idea that the only way to succeed financially was extracting value from others, or giving up on what I found meaningful. I couldn't find a system that worked for me, so I created it — across science, entrepreneurship, research, and investing, through successful companies and failed ones, breaking molds instead of breaking down. I'm here, in an ever-changing world, still incurably optimistic.

Investor Entrepreneur Scientist
100+Startups Invested In
15Companies Built, Sold, or Closed
7Books Authored
16VC Funds, as LP

What I Do

Invest. Educate. Care.

Four decades of creating, growing, pivoting, selling, merging, or closing companies of my own — now a foundation for investing intentionally, for my family and for others.

Invest

My investment approach combines strategic rigor with a commitment to disrupting traditional venture capital models. Through the Wealthing VC Club—a framework I pioneered that others have since tried to replicate—I deploy my own capital while inviting members to co-invest alongside me on a deal-by-deal basis. Beyond venture capital, my portfolio extends into real estate, hospitality, and fine art collecting, applying both capital and taste to whatever is genuinely well-built. Maintaining an average annual pace of 5 to 7 new investments, 8 to 10 follow-ons, and 4 to 5 exits, I focus on backing high-impact sectors and reshaping how early-stage capital flows to transformational ideas worldwide.

Wealthing VC Club →

Educate

My education journey began as a professor in Venezuela and evolved into designing disruptive models that create wealth, democratize investing, and challenge traditional financial systems. After developing Chile's national entrepreneurship curriculum in 1999, I expanded my mission through the Wealthing Institute—building innovative frameworks that bridge venture capital for individual accredited investors and family offices alike. Having trained scientists, professors, and founders across five continents in Latin America, North America, Europe, Asia, and Australia, my work focuses on demystifying venture development, unlocking access to capital, and teaching others how to turn bold ideas into scalable, wealth-generating enterprises.

Wealthing Institute →

Care

My care is deeply rooted in gratitude for the countless people who have helped me along the way—from a gifted winter coat or homemade soup to free rent and patient explanations of complex concepts. Care is embedded in everything I do and extends across generations, as my children and grandchildren dedicate their time to supporting causes they believe in. We routinely contribute anonymously, and I set aside half a day every week to volunteer with organizations centered on happiness, learning, and inclusion. Through quietly transformative initiatives like Box of Life, which my daughter helped organize, we work together to enrich lives and build a more fulfilling world, one box at a time.

Box of Life →

A Bit Human

I am an incurable optimist, a strategist who loves numbers, and someone who never learned to identify people by their profiles.

Agronomy Engineering · MSc, Biotechnology · MBA · PhD, Finance & Entrepreneurship · AICD · NLP

Born and raised in Venezuela in 1961, I grew up in a small town beside a tropical cloud forest and built my own world of magic long before I built investment vehicles. I studied Agronomy to help solve hunger — the theme never left me, and today it lives on through Box of Life.

In 1994, I moved from Venezuela to the United States and built my career and wealth from the ground up, several times over: creating, closing, and selling companies; investing, losing, and investing again. I've studied continuously, worked across many countries, and spoken and taught in many more — including a TEDx stage.

Much of this journey was shared by my two children, Daniel Chapellin Castillo and Sara Perry, who moved countries with me, learned new languages, and kept me grounded — sometimes confused, and always amused. I'm close to them and to their families now, and together we're rewriting how our family office works, around values we all share.

I started working early — as a research assistant in the summers, a daycare assistant during the school year, doing translations and transcriptions on the side. I played in a band, danced, hiked, and, to this day, still grow vegetables. I presented my first research paper, on plant viruses, at 16 — with no idea I'd eventually trade science for corporate R&D, opera, and entrepreneurship.

I've lived across 4 continents — Latin America, North America, Europe, and Australia — and taught or spoken in many more. Along the way, I helped pioneer Chile's entrepreneurial ecosystem: launching Chile's first Centre for Entrepreneurship and the country's first Seed Capital Fund.

After years across many countries, I eventually landed in Silicon Valley. Shortly after arriving, I joined Sand Hill Angels, co-chairing the life sciences group and serving on the board. I invest in 10–12 companies a year, across life sciences, climate, and disruptive technology. I also launched Women Get Funded, the only program of its kind, and — for reasons that still surprise me — once built a hotel in Sacramento. In 2020, I launched Wealthing VC Club with my son and co-founder, Daniel; I host The Wealthing Podcast, direct the Wealthing Institute, travel constantly, and still make time for my family and my garden. Wealthing has been the guiding principle throughout: choosing to create wealth, not extract it.

Alicia Castillo Holley with her children, Daniel Chapellin Castillo and Sara Perry, in Paris Alicia with her children, Daniel Chapellin Castillo and Sara Perry, in Paris Quirky, but true

I fought off a monkey that broke into my house and attacked my kids.

I fell off a horse at 13 and was in a coma for several days.

I presented my first research paper at sixteen.

I dance salsa and tango, and I play the cuatro.

I collect art, and I've developed a hotel — because taste and capital shouldn't stay in separate rooms.

I don't watch TV. I have 4 grandchildren and have visited over 100 countries.

What I Learned the Hard Way

You are extracting, or you are being extracted from.

The narrative I grew up hearing in a small town in Venezuela, praising socialism, is the same narrative I now hear in many family office meetings. Strip away the politics, and poor and rich people often share the same view of wealth: you are extracting, or you are being extracted from. I wanted a different approach — where my family and I use money as a tool for progress, so nobody has to lose for us to win.

01

I learned I could be happy, or I could be wealthy — until I learned that was a false choice, one I'd been sold, not one that was true.

02

I learned that creating knowledge doesn't create wealth, and creating wealth doesn't create generational wealth. Each is a different discipline, earned separately, on its own timeline.

03

I learned that money is an instrument — of progress, or of oppression. I chose the former. That choice is why I became an entrepreneur, and why I now invest in founders who are creating new wealth, not just capturing it: returns, jobs, taxes, services.

If any of this sounds like your own reckoning — with wealth, with purpose, or with what to do now that you've made it — I'd like to talk.

Speaking

Keynote Speaker

I speak on venture capital, wealth creation, and building across science, entrepreneurship, and investing — customized to the audience and the event.

Experience

Been there, done that — failed, succeeded, and everything in between.

Passion

All about touching people's hearts and minds.

Engagement

A lingering sense of contribution, resilience, and impact.

Depth

A profound reflection on one's impact on others.

For Organizers & Press

Media Kit

Approved photos and ready-to-use bios, so your program gets the right photo and the right words — no guessing required.

Alicia Castillo Holley, PhD — approved press and speaker photo Download high-res photo →
Short — 50 words

Dr. Alicia Castillo Holley is a Silicon Valley venture capitalist, author, and serial entrepreneur. Originally a plant scientist from Venezuela, she pioneered Latin American venture capital by founding Chile's first seed fund. She holds a PhD in finance and leads the Wealthing VC Club, investing in high-impact post-seed deals.

Medium — 100 words

Dr. Alicia Castillo Holley is a prominent venture capitalist, serial entrepreneur, author, and educator. Starting her career as an agronomy researcher in Venezuela, she transitioned into business, earning an MBA from Babson College and a PhD in finance from the University of Western Australia. A pioneer in Latin American venture capital, she established Chile's first seed capital fund and entrepreneurship center. Today, based in Silicon Valley, she is the founder of the Wealthing VC Club and her own family office, Wealthing Group. She is known for her interest in life sciences, climate, energy, and space, and is a keen supporter of diversity and inclusion.

Long — 200 words

Dr. Alicia Castillo Holley is a Silicon Valley venture capitalist, serial entrepreneur, author, and academic who advocates for using wealth creation as a force for social progress. Originally from Venezuela, she began her career as an agronomy researcher before moving into corporate product development and starting her own ventures. After earning an MBA from Babson College, she moved to Chile, where she played a pivotal role in building the regional startup ecosystem by founding the country's first entrepreneurship center and its first seed capital fund. After two decades trotting the world, she moved to Silicon Valley in 2013, actively investing in promising post-seed deals in life sciences, climate, energy, space, and others. Holding a PhD in Finance and Entrepreneurship from the University of Western Australia, Dr. Castillo Holley has founded over 15 organizations and backed hundreds of startups worldwide. She serves as the Founder and CEO of the Wealthing VC Club and her Family Office, the Wealthing Group. A passionate champion for diversity and equity, she created initiatives like Women Get Funded to train female entrepreneurs. Her career spans scientific research, venture investing, and philanthropic impact across multiple continents.

As a Guest

Conversations elsewhere

I'm a regular guest on shows covering investing, resilience, and building a family office.

Family Office Insights US

From Venezuela to Venture Capital

My journey from plant genetics researcher to venture capitalist, and everything that happened in between.

Wealthing VC Club

Watch Our Intro

A short introduction to the club, how it works, and who it's built for.

Money Tales

Money for Progress, Not Oppression

Leaving Venezuela with $600 and two kids, and why money should serve progress rather than oppression.

Investor Connect — Ep. 841

From Scientist to Venture Capitalist

A conversation with Hall Martin on the journey from research to running Wealthing VC Club.

Silicon Valley Impact — S2 E14

A Disruptive Model for Venture Capital

On building a due-diligence and post-investment process that gives family offices real access to vetted deals.

Arrivals: Stories of Resilience

A World Citizen

Movement, independence, and resilience — six countries, lectures in thirty more, and a life built along the way.

The Bliss Business Podcast

Bliss Investing

Why empathy, connection, and consciousness belong in venture capital, not just financial models.

Venezuela Diaspora Project

A Venezuelan Angel Investor in San Francisco

From plant genetics research in Venezuela to backing diverse founders in Silicon Valley.

Theory of Change, with Benjamin Ulrich

Transforming Venture Capital for Family Offices

How traditional VC needs to evolve to better serve family offices and impact-driven investors.

GSD Venture Studios, with Gary Fowler

Can Venture Capital Work?

Rethinking wealth creation and high-impact investing — moving VC beyond extraction toward value creation.

Productive Passions, with Christy Tagye

Build Something Worth Funding

Founder lessons on money, failure, and real wealth — building value with clarity and humility before chasing validation.

ScaleUp Africa, with Amma Gyampo

Venture Club, Blended Finance, Africa

On building an investment club model and blended finance structures to bring catalytic capital into African markets.

Portfolio

Companies I've invested in

Across venture, real estate, and direct deals — 84 companies and counting.

Profusa X-Mode Owl AI Sandstone myLAB Box Eridan Communications Tribe Carta SPV ECFX PlusPlus Inhalon Biopharma Tribe Shiprocket SPV Orbit Fab Sonavi Labs GPO Fund I — Centivo SPV GPO Fund I — Fund That Flip SPV GPO Fund I — Pangaea SPV / OpenBorder GPO Fund I — Newlight SPV GPO Fund I — Upflex FO Saccharo Tau Drip Agtools Avenda Health ClimateView DataBento De Oro Devices DermaSensor Embr Labs Ettitude Fundbox Grover InnerPlant Invasive Species Corporation Jericho Security Lettuce Grow Lynk Madison Reed Mahila Money Materna Medical Matternet Mussel Polymers Nanochon Nopalera OpenBorder Pangaea Paradromics ReCharge Rejuvenate Bio Sinaptica Therapeutics Skycatch, Inc. Tandem PV ThreatQuotient UpFlex Upright VenoStent ViewMind Wavely Diagnostics World (prev. Worldcoin) Yumi Interabang Entertainment Shades and Highlights Spinnakr Peloton e-Chromic Cargo Chief CrowdMics CirrusMD Savioke Angaza Magnetic Insight Krome Photo New Wave Foods Buoy Labs Tivic Health OnScale SellHound Gerostate Alpha Volumetric Biotechnologies Imprint Energy BETA Technologies Iris Automation Literati OnlySky The Planting Hope Company Inc. Turn Bio

Limited Partner

Funds I'm invested in as an LP

Illuminate I Illuminate Opportunity Ares Energy KKR Special Stepstone Fresco Capital Liquid2 Aligned Partners OurCrowd Top Tier Fund L2 Opportunity Fund Right Side Capital Fund IV Liquid2 Fund III Tribe Capital II / Sethi III Aruwa Capital Management Fjor Gaingels Holding

Books

What I've written

The Ten Unwealthy Habits

Take the Breaks Off

Ten invisible habits that keep capable people stuck with money — with a remedy for each one.

How to Fund Your Million Dollar Idea

Stop wasting time and find the ideal fit for your funding needs

A practical guide to matching the right capital mechanism to the right stage of your company.

Creando Empresas Fabulosas

Cómo Crear, Reinventar y Financiar Empresas de Alto Impacto

A Spanish-language guide to creating, reinventing, and funding high-impact companies.

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