Founder & CEO, Wealthing VC Club
I didn't like the idea that the only way to succeed financially was extracting value from others, or giving up on what I found meaningful. I couldn't find a system that worked for me, so I created it — across science, entrepreneurship, research, and investing, through successful companies and failed ones, breaking molds instead of breaking down. I'm here, in an ever-changing world, still incurably optimistic.
What I Do
Four decades of creating, growing, pivoting, selling, merging, or closing companies of my own — now a foundation for investing intentionally, for my family and for others.
My investment approach combines strategic rigor with a commitment to disrupting traditional venture capital models. Through the Wealthing VC Club—a framework I pioneered that others have since tried to replicate—I deploy my own capital while inviting members to co-invest alongside me on a deal-by-deal basis. Beyond venture capital, my portfolio extends into real estate, hospitality, and fine art collecting, applying both capital and taste to whatever is genuinely well-built. Maintaining an average annual pace of 5 to 7 new investments, 8 to 10 follow-ons, and 4 to 5 exits, I focus on backing high-impact sectors and reshaping how early-stage capital flows to transformational ideas worldwide.
Wealthing VC Club →My education journey began as a professor in Venezuela and evolved into designing disruptive models that create wealth, democratize investing, and challenge traditional financial systems. After developing Chile's national entrepreneurship curriculum in 1999, I expanded my mission through the Wealthing Institute—building innovative frameworks that bridge venture capital for individual accredited investors and family offices alike. Having trained scientists, professors, and founders across five continents in Latin America, North America, Europe, Asia, and Australia, my work focuses on demystifying venture development, unlocking access to capital, and teaching others how to turn bold ideas into scalable, wealth-generating enterprises.
Wealthing Institute →My care is deeply rooted in gratitude for the countless people who have helped me along the way—from a gifted winter coat or homemade soup to free rent and patient explanations of complex concepts. Care is embedded in everything I do and extends across generations, as my children and grandchildren dedicate their time to supporting causes they believe in. We routinely contribute anonymously, and I set aside half a day every week to volunteer with organizations centered on happiness, learning, and inclusion. Through quietly transformative initiatives like Box of Life, which my daughter helped organize, we work together to enrich lives and build a more fulfilling world, one box at a time.
Box of Life →A Bit Human
Agronomy Engineering · MSc, Biotechnology · MBA · PhD, Finance & Entrepreneurship · AICD · NLP
Born and raised in Venezuela in 1961, I grew up in a small town beside a tropical cloud forest and built my own world of magic long before I built investment vehicles. I studied Agronomy to help solve hunger — the theme never left me, and today it lives on through Box of Life.
In 1994, I moved from Venezuela to the United States and built my career and wealth from the ground up, several times over: creating, closing, and selling companies; investing, losing, and investing again. I've studied continuously, worked across many countries, and spoken and taught in many more — including a TEDx stage.
Much of this journey was shared by my two children, Daniel Chapellin Castillo and Sara Perry, who moved countries with me, learned new languages, and kept me grounded — sometimes confused, and always amused. I'm close to them and to their families now, and together we're rewriting how our family office works, around values we all share.
I started working early — as a research assistant in the summers, a daycare assistant during the school year, doing translations and transcriptions on the side. I played in a band, danced, hiked, and, to this day, still grow vegetables. I presented my first research paper, on plant viruses, at 16 — with no idea I'd eventually trade science for corporate R&D, opera, and entrepreneurship.
I've lived across 4 continents — Latin America, North America, Europe, and Australia — and taught or spoken in many more. Along the way, I helped pioneer Chile's entrepreneurial ecosystem: launching Chile's first Centre for Entrepreneurship and the country's first Seed Capital Fund.
After years across many countries, I eventually landed in Silicon Valley. Shortly after arriving, I joined Sand Hill Angels, co-chairing the life sciences group and serving on the board. I invest in 10–12 companies a year, across life sciences, climate, and disruptive technology. I also launched Women Get Funded, the only program of its kind, and — for reasons that still surprise me — once built a hotel in Sacramento. In 2020, I launched Wealthing VC Club with my son and co-founder, Daniel; I host The Wealthing Podcast, direct the Wealthing Institute, travel constantly, and still make time for my family and my garden. Wealthing has been the guiding principle throughout: choosing to create wealth, not extract it.
I fought off a monkey that broke into my house and attacked my kids.
I fell off a horse at 13 and was in a coma for several days.
I presented my first research paper at sixteen.
I dance salsa and tango, and I play the cuatro.
I collect art, and I've developed a hotel — because taste and capital shouldn't stay in separate rooms.
I don't watch TV. I have 4 grandchildren and have visited over 100 countries.
What I Learned the Hard Way
The narrative I grew up hearing in a small town in Venezuela, praising socialism, is the same narrative I now hear in many family office meetings. Strip away the politics, and poor and rich people often share the same view of wealth: you are extracting, or you are being extracted from. I wanted a different approach — where my family and I use money as a tool for progress, so nobody has to lose for us to win.
I learned I could be happy, or I could be wealthy — until I learned that was a false choice, one I'd been sold, not one that was true.
I learned that creating knowledge doesn't create wealth, and creating wealth doesn't create generational wealth. Each is a different discipline, earned separately, on its own timeline.
I learned that money is an instrument — of progress, or of oppression. I chose the former. That choice is why I became an entrepreneur, and why I now invest in founders who are creating new wealth, not just capturing it: returns, jobs, taxes, services.
If any of this sounds like your own reckoning — with wealth, with purpose, or with what to do now that you've made it — I'd like to talk.
Speaking
I speak on venture capital, wealth creation, and building across science, entrepreneurship, and investing — customized to the audience and the event.
Been there, done that — failed, succeeded, and everything in between.
All about touching people's hearts and minds.
A lingering sense of contribution, resilience, and impact.
A profound reflection on one's impact on others.
For Organizers & Press
Approved photos and ready-to-use bios, so your program gets the right photo and the right words — no guessing required.
Dr. Alicia Castillo Holley is a Silicon Valley venture capitalist, author, and serial entrepreneur. Originally a plant scientist from Venezuela, she pioneered Latin American venture capital by founding Chile's first seed fund. She holds a PhD in finance and leads the Wealthing VC Club, investing in high-impact post-seed deals.
Dr. Alicia Castillo Holley is a prominent venture capitalist, serial entrepreneur, author, and educator. Starting her career as an agronomy researcher in Venezuela, she transitioned into business, earning an MBA from Babson College and a PhD in finance from the University of Western Australia. A pioneer in Latin American venture capital, she established Chile's first seed capital fund and entrepreneurship center. Today, based in Silicon Valley, she is the founder of the Wealthing VC Club and her own family office, Wealthing Group. She is known for her interest in life sciences, climate, energy, and space, and is a keen supporter of diversity and inclusion.
Dr. Alicia Castillo Holley is a Silicon Valley venture capitalist, serial entrepreneur, author, and academic who advocates for using wealth creation as a force for social progress. Originally from Venezuela, she began her career as an agronomy researcher before moving into corporate product development and starting her own ventures. After earning an MBA from Babson College, she moved to Chile, where she played a pivotal role in building the regional startup ecosystem by founding the country's first entrepreneurship center and its first seed capital fund. After two decades trotting the world, she moved to Silicon Valley in 2013, actively investing in promising post-seed deals in life sciences, climate, energy, space, and others. Holding a PhD in Finance and Entrepreneurship from the University of Western Australia, Dr. Castillo Holley has founded over 15 organizations and backed hundreds of startups worldwide. She serves as the Founder and CEO of the Wealthing VC Club and her Family Office, the Wealthing Group. A passionate champion for diversity and equity, she created initiatives like Women Get Funded to train female entrepreneurs. Her career spans scientific research, venture investing, and philanthropic impact across multiple continents.
Featured Videos
Lessons learned building a VC fund: dream big, plan to execute, invite others, evaluate, enjoy, rest.
Samsung Innovation CenterMajor trends and opportunities: humans as ecosystems, full integration, automation, and validation.
SuperTech Event, San Francisco"It isn't a small group of people that changes the world — it's a small group of diverse people that can."
Co-Creating InnovationBuilding collaboration and growth between two worlds that rarely talk to each other.
Gold Coast, AustraliaSuccesses and failures, discussed honestly — a refreshing approach to high-impact entrepreneurship.
Tech Superwomen Summit, SFA fireside chat with DJ Patil and Todd Park, Technology Advisor to the White House, on what it actually takes to shift the numbers.
Silicon Zombies, Live at Startup GrindOn why reducing capital needs — not just raising more — is the real way to protect equity in the largest capital reallocation in history.
As a Guest
I'm a regular guest on shows covering investing, resilience, and building a family office.
My journey from plant genetics researcher to venture capitalist, and everything that happened in between.
Wealthing VC ClubA short introduction to the club, how it works, and who it's built for.
Money TalesLeaving Venezuela with $600 and two kids, and why money should serve progress rather than oppression.
Investor Connect — Ep. 841A conversation with Hall Martin on the journey from research to running Wealthing VC Club.
Silicon Valley Impact — S2 E14On building a due-diligence and post-investment process that gives family offices real access to vetted deals.
Arrivals: Stories of ResilienceMovement, independence, and resilience — six countries, lectures in thirty more, and a life built along the way.
The Bliss Business PodcastWhy empathy, connection, and consciousness belong in venture capital, not just financial models.
Venezuela Diaspora ProjectFrom plant genetics research in Venezuela to backing diverse founders in Silicon Valley.
Theory of Change, with Benjamin UlrichHow traditional VC needs to evolve to better serve family offices and impact-driven investors.
GSD Venture Studios, with Gary FowlerRethinking wealth creation and high-impact investing — moving VC beyond extraction toward value creation.
Productive Passions, with Christy TagyeFounder lessons on money, failure, and real wealth — building value with clarity and humility before chasing validation.
ScaleUp Africa, with Amma GyampoOn building an investment club model and blended finance structures to bring catalytic capital into African markets.
The Wealthing Podcast
Authentic conversations about life lessons — with investors, founders, and family offices building beyond the traditional narratives of competition. Money first, but not money only.
A former hedge fund manager on leaving institutional finance to launch Earth-to-Mars Capital, betting on frontier space a decade before it was consensus.
Inclusive CapitalFrom Managing Director at NASDAQ to founder of L'ATTITUDE Ventures and Libra Leaders — investing at the intersection of AI and Latino, women-led founders.
Deep TechFrom 1990s programmer to Silicon Valley technology architect, on backing quantum computing and AI across cybersecurity and materials science.
ClimateA three-time founder on embedding captured carbon into industrial supply chains, and the trillion-dollar market hiding inside carbon removal.
Impact FinanceCo-founder of Canada's first institutional VC fund focused on Black founders, on geographic bias and building capital access from Montreal to Kenya.
AI & StrategyBuilding a SaaS platform that simulates decision-making — and what it means to design AI systems that help, rather than replace, human judgment.
Portfolio
Across venture, real estate, and direct deals — 84 companies and counting.
Limited Partner
Books
Take the Breaks Off
Ten invisible habits that keep capable people stuck with money — with a remedy for each one.
Stop wasting time and find the ideal fit for your funding needs
A practical guide to matching the right capital mechanism to the right stage of your company.
Cómo Crear, Reinventar y Financiar Empresas de Alto Impacto
A Spanish-language guide to creating, reinventing, and funding high-impact companies.